By ROKU GODA/ Staff Writer
January 23, 2020 at 18:25 JST
Bottles of liquid glue whose major component is polyvinyl alcohol (Asahi Shimbun file photo)
A major component in liquid glue dramatically increases the effects of cancer radiation therapy, a research team at the Tokyo Institute of Technology has discovered.
The team's findings were released Jan. 23 in the U.S. scientific journal Science Advances.
In a radiation therapy called boron neutron capture therapy (BNCT), a drug made of boron compounds is injected into cancer cells before neutrons are irradiated from outside to destroy those cells.
In experiments using mice with colon cancer, the team said it inhibited cancer cell growth almost completely by mixing the drug with polyvinyl alcohol (PVA), a component of liquid glue.
After receiving injections of the mixture, the animals' cancer cells barely grew, achieving “a level of near eradication of cancer,” according to the team.
“It’s easy to make the drug since you only need to mix PVA into it, and it’s highly practical,” said Takahiro Nomoto, an assistant professor at the Tokyo Institute of Technology, adding the team hopes to apply the practice in a clinical setting.
One downside of BNCT is that boron compounds can easily leak from cancer cells.
Mixing boron compounds with PVA is believed to turn the drug into a slime-like gel, enabling cancer cells to retain it more easily.
Molecules of boron compounds were observed to grow in length when mixed with PVA.
When the team combined PVA with the drug, the cells accepted roughly three times as many boron compounds, which also stayed inside the cells longer than usual.
Clinical studies of BNCT are being conducted at nearly 10 medical institutions in the country.
Scientists have high hopes that BNCT will become a next-generation radiation therapy since it causes little damage to normal cells.
Visit this page for the latest news on Japan’s battle with the novel coronavirus pandemic.
Cooking experts, chefs and others involved in the field of food introduce their special recipes intertwined with their paths in life.
Haruki Murakami and other writers read from books before selected audiences at the new Haruki Murakami Library.
The Asahi Shimbun aims “to achieve gender equality and empower all women and girls” through its Gender Equality Declaration.
Let’s explore the Japanese capital from the viewpoint of wheelchair users and people with disabilities with Barry Joshua Grisdale.